Pack smart and load up efficiently. I organized each family member's clothes in large zip-top bags that I stacked in their closet area. Dirty clothes went into a large communal bag.
Place heavy dishes, pots and pans in bottom cupboards and lighter objects up higher. We learned this the hard way—five minutes after pulling out from my in-laws' driveway, we hit a pot hole and every cupboard and drawer flew open. Dishes crashed to the floor and boxes of graham crackers sailed across the RV. I almost insisted on abandoning ship to the nearest Four Seasons, but I resisted.